Synopsis

“IRC / ISSB-P advanced course on cancer biology and therapy” is the first educational event in molecular oncology and precision medicine in morocco.
The course is oriented to oncologists, hematologists, radiotherapists, pathologists, pharmacists, and biologists.
The main objective is to offer an up-to-date course on the molecular oncology, and new therapeutic approaches.
International and national key speakers will provide lectures on different topics in the field of precision oncology ranging from molecular mechanisms to therapeutic applications.
The course will provide workshop sessions developed specifically to discuss the clinical implementation of new technologies into clinical practice.

Learning objectives
– To understand the basics of cancer development
– To understand the basics of cancer immunotherapy and their applications
– To learn about the current and upcoming molecular approaches to implement precision oncology.
– To understand the challenges regarding the interpretation and the clinical utility of molecular profiling results.
– To learn about current and potential applications of liquid biopsies to evaluate blood-based biomarkers and to develop more effective therapeutic strategies based on a molecular monitoring of the disease.
– To learn about genetic testing and counseling in hereditary cancer for
patients and their families

To launch the “MoON” Network : Moroccan Oncogenetics Network MoON
• Presentation of the MooN 2020-2023: action plan
• Presentation of the National steering committee

Key sessions
_Cancer cell and tumor micro-environnement
_Precision medicine: Integrating new technologies into clinical practice _Hereditary cancer genetics
_Drug development in Oncology

Target audience
This course is oriented to clinicians (oncologists, radiotherapists,
onco-hematologists, Pathologists), pharmacists, and biology researchers interested in molecular oncology. 50 participants will attend the event in person. The meeting will be streamed live and the e-sessions will be available according to the presenter’s agreement to release them.

Program
October 20th 2021 Reception of th e participants, visit of the laboratories and Opening Ceremony
Day 1 October 21st 2021 Hereditary Cancer GeneticsCancer therapy and drug development
Day 2 October 22nd 2021 Cancer genomic and precision oncology Biobanking and Big data for precision oncology
Day 3 October 23rd 2021 Tumor microenvironement and Immun oncology

– Siham CHAFAI EL ALAOUI Hereditary breast and ovarian cancer: BRCA and beyond
– Leila BOUGNOUCH Hereditary gastrointestinal cancer
– Ilham RATBI Hereditary syndromes in neuroendocrine tumors
– Yassamine DOUBAJ Rare hereditary diseases with defects in DNA repair

– Patricia MARTIN ROMANO : Drug development in the era of precision medicine – Biomarkers: Selection and Validation
– Simon BENITA : The design and evaluation of a new lipophilic Platinum(IV) oxaliplatin derivative
– Armand BENSUSSAN : Development of new nonchemotherapy treatment for cutaneaous T cell lymphomas

– Hugues DETHE : Deciphering leukemia pathogenesis through therapy response.
– Robert WYNN : Using allogeneic Cord Blood Transplantin Refractory Haematological Malignancy in Children
– Anass BELBACHIR : Cell therapy in oncology

– Houcine OUAFIK : Genomic instability and drivers in cancer development
– Fadila GUESOUS : Epigenetic changes in cancer: miRNA
– Rachid EL FATIMY : New nuelear function for miRNA as a modulator of splicing machinery in Glioblastoma

– Houcine OUAFIK : Clinical implementation of NGS; organisation and the role of MTB – « Molecular tumor board »: case discussion

– Keith CRANDALL : Metagenomics: new horizon in cancer research

– Kurt ZATLOUKAL : Biobanking: why it is important? – Artificial intelligence and Big data in oncology
– Maud TOULMONDE : OSIRIS a model of Data Set for Data Sharing and Interoperability in Oncology

– Henry Silverman : Ethical issues regarding Big Data in Research
– Abdellah MADANI : Cytogenetic and molecular testing in Chronic Lymphocytic Leukemia and Multiple Myeloma. Practical aspects

– Farid HAKKOU : Data protection in heathcare and biomedical resaerch in Morocco
– Omar SEGHROUCHNI : Implementing precision medicine: personnel data protection and the ethical challenges

– Florent PETIPREZ : Tumor micro-environment.
– Mohammed EL AZAMI EL IDRISSI : Tumor immunology
– Sanae BEN MKADDEM : Antigen receptors as molecular switches regulating inflammation

– Saber Boutayeb : Anti PD1/PD-L1immun otherapy and current predictive biomarkers
– Antonio CARRASCO YALÁN : How does CART-cell therapy work in treating cancer?
– Hicham EL ATTAR :Biomarkers in immuno–oncology
– Franck PAGÈS : Pronostic and predictive value of the immunoscore in patients with colorectal cancers. – Mechanisms of resistance to immunotherapy